Explore the Science Behind CVAC

CVAC isn't just new—it's backed by real data and physiological mechanisms that push the boundaries of human performance, recovery, and longevity. This page gives you a high-level view of how CVAC works, what the science says, and what mechanisms are activated in your body during every session.

Preview Featured Studies

Stanford Glucose Metabolism Study
Explored CVAC's role in metabolic adaption and glutcose utilization.

Marquez JL, Rubinstein S, Fattor JA, Shah O, Hoffman AR, Friedlander AL. Cyclic hypobaric hypoxia improves markers of glucose metabolism in middle-aged men. High Altitude Medicine & Biology 2013;14(3):263-72

University of Hawaii Cardiovascular Performance Trial
Measured VO2 max, oxygen effeciency and endurance gains.

Hetzler RK, Stickley CD, Kimura IF, LaBotz M, Nichols AW, Nakasone KT, et al. The effect of dynamic intermittent hypoxic conditioning on arterial oxygen saturation. Wilderness & Environmental Medicine 2009;20(1):26-32.

UCSD Pain and Quality of Life Study
Evalauted reported pain levels, mood improvements and recovery metrics.

Herbst KL, Rutledge T. Pilot study: rapidly cycling hypobaric pressure improves pain after 5 days in adiposis dolorosa. Journal of Pain Research 2010;3:147–53.

1. Performance and Oxygenation

Summary

CVAC’s pressure cycles drive cellular-level oxygen adaptation, boosting endurance, circulation, and overall athletic output.

Studies and Evidence
  • University of Hawaii Study: Demonstrated statistically significant increases in VO2 max and oxygen-carrying capacity in CVAC group vs controls.
  • Stanford Cyclists Data (Anecdotal): Marked improvements in endurance, oxygen efficiency, and power output.
  • High-Altitude Native Comparison: Mimics adaptations observed in elite high-altitude athletes.
Mechanisms of Action
  • HIF-1α Activation: Triggers red blood cell production and angiogenesis.
  • Intermittent Hypoxia: Promotes oxygen economy, vascular flexibility, and deeper capillary beds.
  • Enhanced NO Signaling: Expands vascular diameter and optimizes oxygen delivery.

2. Metabolic Health & Insulin Sensitivity

Summary

CVAC improves glucose metabolism and mitochondrial density without requiring exercise or caloric restriction.

Studies and Evidence
  • Stanford Insulin Resistance Study: Statistically significant improvements in fasting glucose and oral glucose tolerance in CVAC subjects.
  • Mitochondrial Deficiency & Diabetes Link: Supported by numerous external metabolic health studies.
Mechanisms of Action
  • Mitochondrial Biogenesis: Boosts cellular efficiency in processing glucose and fats.
  • NO-Mediated Glucose Uptake: Improves vascular insulin transport and peripheral glucose usage.
  • Adaptive Hypoxia: Conditions cells to become metabolically flexible.

3. Brain Health and Concussion Recovery

Summary

CVAC may support neuroprotection and brain recovery by enhancing oxygen resilience and fluid circulation.

Studies and Evidence
  • NFL Concussion Altitude Study: Games played at altitude showed lower concussion incidence.
  • Mitochondrial Dysfunction in TBI: Points to hypoxia-driven brain repair mechanisms.
  • Anecdotal Recovery Reports: Numerous cases of post-concussive symptom relief following CVAC
Mechanisms of Action
  • Hypoxia Conditioning: Builds brain tolerance to oxygen stress.
  • Glymphatic Activation: Supports clearance of neurotoxins and metabolic byproducts.
  • Mitochondrial Repair Pathways: Elevates ATP and neuroplasticity.

4. Lymphatic & Glymphatic Activation

Summary

Pressure cycling acts like a passive lymphatic massage — improving detox, circulation, and
inflammation resolution.

Studies and Evidence
  • Glymphatic System Research: Shows that mechanical movement enhances brain
    waste clearance.
  • CVAC Case Reports: Observed improvements in Parkinson’s, ALS, and cognitive fog.
Mechanisms of Action
  • Dynamic Pressure Rhythms: Physically move lymph and cerebrospinal fluid (CSF).
  • Deep Breathing Stimulation: Enhances thoracic lymphatic drainage.
  • NO-Mediated Vascular Flow: Increases waste filtration and clearance.

5. Anti-Aging & Regeneration

Summary

By supporting detox and mitochondrial function, CVAC offers longevity and regenerative
potential at the cellular level.

Studies and Evidence
  • AGEs Research: Accumulation of glycation byproducts linked to aging diseases; CVAC may help clear them.
  • Mitochondrial Decline and Aging Studies: Correlate organelle dysfunction with aging.
Mechanisms of Action
  • Lymphatic Mobilization: Clears pro-aging waste molecules.
  • Cell Membrane Flexing: Enhances metabolic waste excretion.
  • Mitochondrial Support: Maintains cellular vitality over time.

6. Pain, Weight & Mental Health

Summary

CVAC’s systemic effects reduce inflammation, improve energy, and support mental clarity.

Studies and Evidence
  • UC San Diego Pain Pilot: Reported significant reductions in pain, weight, and brain fog after using CVAC.
  • Tempus Clinic Subject: VO2 max, testosterone, and insulin levels improved.
Mechanisms of Action
  • Mitochondrial Upregulation: Supports recovery, reduces chronic fatigue.
  • Hypoxia & Endorphin Adaptation: Enhances feel-good neurochemistry.
  • Lymphatic Clearance: Resolves stagnant inflammation and pain.

7. Cellular Adaptation & Mitochondria

Summary

CVAC stimulates mitochondrial biogenesis and cellular resilience — building long-term
metabolic power and resistance to disease.

Studies and Evidence
  • Transient Hypoxia Research: Improves mitochondrial replication and function.
  • Nitric Oxide Pathway Studies: Show increased mitochondrial transcription and ATP output.
Mechanisms of Action
  • HIF-1α → PGC-1α Cascade: Turns on mitochondrial creation across tissues.
  • Microvoltage (Piezoelectric) Stimulation: Triggers NO production via cell membrane compression.
  • Resilience Programming: Promotes adaptive resistance to stress and aging.

Want the Full CVAC Research Packet?

Get a downloadable PDF of all published and unpublished CVAC studies, case studies, plus supporting science behind performance, metabolic health , brain recovery and more.

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